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Vitamin B-12
Timed release

Nature Made

Vitamin B-12, or cobalamin, is involved in many body processes and works very closely with another B vitamin, folic acid. They both work to synthesize DNA in our body and manufacture red blood cells. Vitamin B-12 is also necessary for the proper functioning of our nervous system. Therefore, if a B-12 deficiency occurs, nerve function can become impaired
and characterized by tingling sensations and numbness. A B-12 deficiency can also cause impaired mental function.

A deficiency in Vitamin B-12 is thought to be quite common among the elderly, and it is a major cause of depression among this age group. In addition, as we age, we have a lower amount of stomach acid secreted that is necessary for vitamin B12 absorption. Vitamin B-12 deficiency is again likely among the elderly population, since we loose the ability
to absorb nutrients as we age. Therefore, it is strongly recommended that people over the age of 50 consume a B-12 supplement.

A deficiency in Vitamin B-12 may also be mistaken for dementia-like symptoms or depression, and patients may end up being mistreated. Folic acid may also mask the symptoms of a B-12 deficiency, so it is recommended that vitamin B-12 and folic acid are taken together. In addition, vitamin B-12 may also play a significant role in heart health. It does so by helping to keep homocysteine levels down in the blood. Homocysteine is a substance that formed when vitamin B-12
and folic acid levels are low, and research has indicated it may be a possible risk factor for heart health.



Vitamin B-12  1000 mcg  /  375 timed release tablets

$58.95    Currency Converter




Directions:  Take one tablet daily with a meal. Keep bottle tightly closed.

 Supplement Facts
 Serving size: 1
tablet                                          Amount Per       % Daily
 Serving Per Container: 375
                                       Serving         Value*
 Vitamin B-12 1000 mcg 16,667%
                                          * Percent Daily Values are based on a 2000 calorie diet.

Other Ingredients:  Dibasic Calcium Phosphate, Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate,

Warnings:  Do not use if imprinted seal under cap is broken or missing.

Storage:  Store in a cool, dry place, out of reach of children.

If you already are taking vitamin B-12, could you still be deficient?

The dietary absorption of vitamin B-12 is complex. It's not just a matter of swallowing a bunch of it (dietary or supplemental) and letting the guts do the work. There is something called "intrinsic factor" which is made in certain cells in the stomach that must be present in order for B-12 to be absorbed at a point in the very end of the small intestine
(the ileum).  

The main sources of B-12 include meat, eggs, and dairy products. Acids in the stomach separate the B-12 from the protein source, at which point it must combine with intrinsic factor. The vitamin B-12 / intrinsic factor complex travels through the intestine and is absorbed in the terminal ileum by cells with specific receptors for the complex.
The absorbed complex is then transported via plasma and stored in the liver. The interruption of one or any combination
of these steps places a person at risk of developing deficiency.

In most cases, vitamin B-12 deficiency is due to an inability of the intestine
to absorb the vitamin, which can happen in several ways.

  1. As we age or become overly reliant on acid suppressing agents like antacids, our ability to produce gastric acids in the stomach decreases, meaning that the B-12 is less likely to be released from its food source.

  2. Deficiency may result from an autoimmune disease that reduces the production or blocks the action of intrinsic factor, or from other diseases that result in intestinal mal-absorption. The most frequent underlying cause of vitamin B-12 deficiency is pernicious anemia, which is associated with decreased production of intrinsic factor.

  3. Also, abdominal surgery may cause B-12 deficiency in several ways. Gastro-ectomy, for example, eliminates the site of intrinsic factor production. Blind loop syndrome results in competition for vitamin B-12 by bacterial overgrowth in the lumen of the small intestine. And surgical resection of the ileum eliminates the site of vitamin
    B-12 absorption.

Other causes of vitamin B-12 deficiency include pancreatic insufficiency, fish tapeworm infection—in which the parasite competes for B-12—and severe Crohn's disease, which results in reduced absorption of B-12 in the intestine


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