SAM-e is involved in
over 40 biochemical reactions in the body. SAM-e is involved in methylation
in the body, which is critical in the manufacturing of many body components,
such as brain neurotransmitters like serotonin and dopamine. SAM-e helps
regulate these neurotransmitters, that affect our mood. SAM-e is also
required for sulfur-containing compounds, such as glutathione, which is a
powerful antioxidant in the body that helps fight off substances that
our cells, particularly in the liver. SAM-e is involved in maintaining and
manufacturing cartilage components. Because of the different reactions SAM-e
is involved, its benefits vary from joint and liver health, to mood
enhancement. SAM-e is recommended to be part of a daily regimen for
Mood/Emotional Well-Being, Bone/Joint Health.
SAM-e (s-adenosylmethionine) is a naturally occurring compound found in
all living organisms. In humans, SAM-e is distributed throughout the body
and is involved in many biochemical processes. Since significant amounts
of SAM-e are not available through diet alone, the body is primarily
responsible for producing its own SAM-e. Scientists know that SAM-e
declines as people age and that certain groups of people, including those
with low mood and liver conditions,
tend to have lower levels of SAM-e in
Researchers studying the beneficial effects of SAM-e have identified the
- Enhances mood by promoting a healthy balance of neurotransmitters, dopamine
and serotonin, which are part of overall healthy brain cell functions.
- Promotes joint health by helping to maintain joint cartilage which naturally
deteriorates with physical activity and age.
- Helps support detoxification and overall healthy liver functions.
Brain Function -
brain function by its methylation effects. Methylation is the process by
which a four atom appendage know as methyl group (unit of one carbon and
three hydrogen atoms) is transferred from one molecule to another.
methyl-donating substances known in mammalian metabolism, SAM-e is the most
important. The donation of methyl groups affects proper function of many
metabolic processes including brain function, energy production and DNA
metabolism. Neurotransmitters, substances involved in the brain's
cell-to-cell communication, are the products of substances in mammalian methylation reactions. These compounds include L-dopa, dopamine, epinephrine
and phospatidyl choline (a component of lecithen).
Energy Production -
SAM-e is critical for proper energy production as it converts
guanidinoacetate to creatine.
Creatine metabolizes to creatine phospate,
which is important for recycling of ADP to ATP. Creatine maximizes
performance, reduces exercise fatigue and improves recovery after exercise
DNA appears to be important in the prevention of DNA imperfections. The
demethylation of DNA is considered to be a contributor to the aging process.
Proper methylation through substances such as SAM-e positively influence
Because SAM-e is a highly reactive molecule, it is very fragile. It degrades
rapidly under conditions of high heat and/or humidity. Improper handling of
SAM-e can cause its degradation in a matter of hours, resulting in a loss of
biological activity. This is why the manufacturing process for SAM-e is done
under low temperature and low humidity, and the
table is enteric coated and
Pharmacokinetic studies show that oral supplementation of SAM-e is most
effective when enteric-coated by special gastric fluid-resistant polymers.
Enteric coating SAM-e results in maximum SAM-e levels in the bloodstream
SAM-e is the same form of SAM-e available and administered for over 20 years
by doctors in Europe.
It is the only form of SAM-e studied in over two
decades of research, as well as the most documented form in respected
journals. Short and long-term studies have proven that SAM-e is a safe,
non-toxic and efficacious products to support your health.